EAA is Not Specific for Endotoxin

Recently the FDA approved the endotoxin activity assay (EAA) for detection of endotoxin in the blood. Several reports, including the one below from the Iwate Medical University in Japan, have shown that while the EAA has a high predictive value of mortality in septic patients, it is more indicative of general infection or inflammation and not specific for endotoxin.

Interleukin-8 induces an elevation in the endotoxin activity assay (EAA) level: does the EAA truly measure the endotoxin level?

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